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CD Genomics Provides Integration Analysis of Whole-Genome Bisulfite and RNA Sequencing for Biomarker Research

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CD Genomics Provides Integration Analysis of Whole-Genome Bisulfite and RNA Sequencing for Biomarker Research

September 24
16:15 2021

New York, USA – September 24, 2021 – CD Genomics, a genomics services company, has become one of the top providers in genomic research, devoting to providing reliable services to pharmaceutical and biotech companies as well as academia and government agencies. CD Genomics offers a variety of services, including genome sequencing, RNA sequencing, epigenomics sequencing, genotyping, and integrated portfolios of multiple sequencing services.

Integration analysis of multiple sequencing data provides a broader view of the genomics research, which comes extremely handy in gene expression and regulation analysis, biomarker identification, bio-interaction analysis, and more. Based on advanced sequencing technology and an experienced team of scientists, CD Genomics provides high-quality integration analysis solutions to facilitate your research work, including whole-genome bisulfite sequencing (WGBS) and RNA sequencing. The combined use of the above two sequencing methods is of great value for the analysis of biomarkers.

Scientists from the Department of Animal Sciences, University of Florida recently conducted a study on bull fertility. The study integrated DNA methylation data with RNA sequencing results and identified candidate markers for sire fertility, and the sample quality check and WGBS were performed by CD Genomics. “A total of 1765 differentially methylated cytosines were found between high- and low-fertility sires. Ten genes associated with 11 differentially methylated cytosines were found in a previous study of gene expression between high- and low-fertility sires,” said the lead author of the research project.

Whole-genome bisulfite sequencing is the gold standard method for obtaining comprehensive base-pair resolution and quantitative information about methylated cytosines in most genomes. It is a reliable strategy that allows for unbiased genome-wide DNA methylation analysis. And RNA-Seq is a tool for mapping and quantifying the transcriptome. It provides an unbiased and unprecedented high-resolution view of the transcription pattern and provides an economical and accurate method for gene expression quantification and differential gene expression analysis,” said Dr. Charlie of CD Genomics.

CD Genomics’s WGBS Service

Before high-throughput sequencing, the DNA sample is processed with cytosine bisulfite conversion followed by tagging at 5′ and 3′ ends, and the introduction of Illumina adapters by PCR amplification. CD Genomics’s highly experienced expert team and strict quality control following every procedure ensure comprehensive and accurate results. The advantages include:

• Highly integrated single-base resolution DNA methylation patterning.
• Providing insights into gene cell-fate commitment and reprogramming, as well as gene regulation.
• Identifying novel epigenetic markers and targets for diseases.

CD Genomics’s RNA-Seq Service

CD Genomics combines both Illumina HiSeq and PacBio systems to provide a fast and accurate RNA-Seq and bioinformatics analysis for any species. Its highly experienced expert team executes quality management, following every procedure to ensure confident and unbiased results. The advantages include:

• Quantitative and precise measurements of RNA molecules at a single base-pair resolution
• Discovery of novel transcripts, splice variants, and gene fusions
• Application to any species, no matter whether reference genome is available
• A comparable or lower price than many other methods

“Our philosophy is to accelerate the development of the biotechnology industry towards breakthrough discoveries. And our goal is to bring the most reliable genome sequencing technology to our customers. For many years, CD Genomics has been committed to providing comprehensive sequencing and analysis services to research institutions and biotechnology companies.” Said Dianna, Marketing Manager of CD Genomics.

About CD Genomics

CD Genomics is a genomics service company with a good reputation for providing reliable sequencing and bioinformatics analysis services, aiming at providing the research community with high-quality Next Generation Sequencing, PacBio SMRT sequencing, and microarray services.

Media Contact
Company Name: CD Genomics
Contact Person: Dianna Gellar
Email: Send Email
Phone: 1-631-259-7705
Country: United States
Website: https://www.cd-genomics.com